| 背景描述 |
Macrophage Colony-Stimulating Factor (M-CSF) is a 19.02 kDa hematopoietic Growth Factors with 162 amino acid residues. The active form of the protein is homodimer, and secreted by osteoblasts. M-CSF controls the production, differentiation, and function of monocytes, macrophages, and bone marrow progenitor cells. M-CSF is able to activate CSF-1 signaling pathway via binding its receptor CSF-1R. |
| 别称 |
macrophage colony-stimulating factor, CSF-1, MGI-IM, CSF1 |
| 蛋白编码 |
P07141 |
| 分子量 |
The protein has a calculated MW of 19.02 kDa.
The protein migrates as 17-25 kDa under reducing condition (SDS-PAGE analysis). |
| 表达系统 |
Escherichia coli |
| 纯度 |
>98% as determined by SDS-PAGE. |
| 生物活性 |
Measure by its ability to induce proliferation in NFS-60 cells.
The ED₅₀ for this effect is <6 ng/mL. |
| 内毒素检测 |
<0.1 EU per 1 μg of the protein by the LAL method. |
| 蛋白序列 |
MKEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSSRDVVTKP withpolyhistidine tag at the C-terminus |
| 蛋白标签 |
His Tag (C-term) |
| 产品形式 |
The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0. If you have any concerns or special requirements, please confirm with us. |
| 产品应用 |
Cell Culture |
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